On-Demand Fundamentals of MicroED
Explore the fundamentals of MicroED, a time saving technique in the toolbox of the synthetic chemist, and gain an appreciation for the theory, advantages, limitations, and applications of MicroED.
About the Instructor(s)
Assistant Professor of Chemistry & Biochemistry, UCLA
Prof. Nelson began his academic career at City College of San Francisco. He then earned a B.S. in Chemistry from University of California at Berkeley in 2005 and a Ph.D. from the California Institute of Technology in 2013. After postdoctoral training at University of California at Berkeley, Prof. Nelson joined the UCLA faculty in 2015. Broadly speaking, Prof. Nelson’s research program is focused on the development of enabling technologies for chemical synthesis. His group approaches this goal through several research areas including reaction discovery, electron crystallography, biocatalysis, and total synthesis.
About the Course
Microcrystal electron diffraction (MicroED) is a type of crystallography where small crystals can be used for structure determination. The technique has rapidly become a powerful tool for molecule structure characterization for synthetic chemists who are unable to grow crystals of a size suitable for X-ray diffraction. This course provides researchers with an understanding of the potential of this technique, including real-world examples, knowledge checks, links to additional resources, and assessments to ensure the information can be applied immediately in the lab.
What You Will Learn
- Recognize the context of MicroED as a powerful tool in the toolkit of a synthetic chemist, including the unique advantages the technique offers
- Understand the theory behind electron diffraction and electron crystallography while articulating the distinctions and similarities with X-ray diffraction/crystallography
- Gain the ability to prepare a sample and acquire electron diffraction data
- Learn the process and workflow for determination of a crystal structure by MicroED
- Identify common statistical parameters encountered during data refinement and their connection to structure quality
Who Should Attend
Researchers in academia, government, and industry who wish to gain an understanding about the use of MicroED and how it relates to other characterization techniques in terms of utility and complexity.
- Introduction to MicroED
- Basics of Electron Crystallography
- Performing MicroED Experiments
- Structural Accuracy, Rigor, and Statistics
- Appropriate Applications of MicroED and Preparing to Collaborate