About the Instructor(s)
Terry Kenakin
Professor, University of North Carolina School of Medicine
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. He is the author of 11 books on Pharmacology.
About the Course
Discover concepts and tools required to make molecules suitable to be drug candidates (i.e., be absorbed, distribute throughout the body, be present to produce effect, and cause no harm).
Key topics include:
- Drug-like properties of molecules
- Absorption (IV, oral, other routes)
- Volume of distribution
- Metabolism (hepatic assays, clearance)
- Excretion (renal clearance)
- In vivo PK (PK-PD models, allometric scaling)
- Drug-drug interactions (hepatic, non linear PK)
- Candidacy for human studies
What You Will Learn
- Understand major concepts of clearance and volume of distribution
- Understand PK in general (ADME), terminology, tools
- Utilize medicinal chemistry to make molecules ADME friendly
- Know the many inexpensive, simple in vitro assays (how to use them, what they give you)
- Know mechanisms of drug-drug interactions, FDA requirements
Who Should Attend
- Medicinal and synthetic organic chemists
- Biologists involved in drug development
- Any scientist involved in the process of drug discovery, production, and approval
Course Outline
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Major Topics
- Drug-like character (physicochemical properties of drugs, in silico techniques, solubility, LogP)
- General concepts of Pharmacokinetics/course sources
- Absorption (advantages of different routes, permeation assays, transporter interactions)
- Plasma Protein Binding (significance, methods to measure, utilization of PPB data)
- Volume of distribution (utilization to estimate drug distribution throughout the body)
- Hepatic metabolism (what can the liver do to your molecule?)
- Estimating hepatic clearance from in vitro hepatic assays
- Hepatic drug-drug interactions (what can your molecule do to the liver?)
- Renal Clearance (excretion, transporter effects)
- In vivo PK (putting it all together)
- Whole body drug-drug interactions, non-linear PK
- Case histories
Dates, Locations, and Prices
Five for four! Register five people for one course, one person for five courses, or any combination in between and your fifth registration is free. The free registration will be the course of the lowest price. Please note: This discount cannot be combined with any other discount offered.
Date and Location: TBD
Course date and location to be posted. Please check back later for schedule update. *Early Bird pricing ends four weeks before the start date of the course.